Mineralocorticoid Receptor Antagonist (MRA) = Aldosterone Antagonist

This group of active substances is used for difficult-to-treat hypertension and in certain forms of heart failure (heart insufficiency). There are additional applications in the context of other underlying conditions, such as fluid retention in liver cirrhosis or in primary hyperaldosteronism.

Mineralocorticoid Receptor Antagonists (MRA)/Aldosterone Antagonists Effects:

Aldosterone is produced in the adrenal gland. It binds to receptors (mineralocorticoid receptors) in the kidney, leading to increased sodium and water reabsorption. As a result, blood pressure rises. When the effect of aldosterone is reduced by the occupation of the receptor by the medication, more sodium and water are excreted, and blood pressure decreases. However, this leads to increased retention of potassium in the body.

Mineralocorticoid Receptor Antagonist (MRA/Aldosterone Antagonist): Aldosterone is produced in the adrenal gland

Mineralocorticoid Receptor Antagonists (MRA)/Aldosterone Antagonists Side Effects:

An important side effect is the increased potassium level in the blood. Compared to other diuretics (see diuretics), MRAs are therefore considered potassium-sparing medications. The increased potassium in the blood can lead to muscle weakness and heart rhythm disturbances. Under the preparation spironolactone, there may be an enlargement of breast tissue in men. Rarely, liver function disorders may also occur.

Please refer to the manufacturer's information for the complete list of side effects.

Mineralocorticoid Receptor Antagonists (MRA)/Aldosterone Antagonists Active Ingredients:

Spironolactone, Eplerenone

Mineralocorticoid Receptor Antagonists (MRA)/Aldosterone Antagonists: Examples of Active Ingredients and Approved Medicinal Products

Sources:

This article is from BloodPressureDB the leading app since 2011 that supports hundreds of thousands in blood pressure monitoring every day. Our content is based on carefully researched, evidence-based data and is continuously updated (as of 03/2024).

Author Dr. med. Christine Berchtold-Benchieb is a specialist in general medicine, studied at LMU Munich, and has worked in clinics as well as in several general and specialist practices. Her long-term, daily care of hypertension patients combines evidence-based competence with practical experience and ensures reliable recommendations.

We hope you found the article on the topic helpful. For good blood pressure management, it is important to take the medications correctly. Our app BloodPressureDB is happy to remind you of the intake times. It also manages the supply and informs you in good time when it is running low. This feature is also fully available in the free version. Get the free app now.