Mineralocorticoid Receptor Antagonist (MRA) = Aldosterone Antagonist

This group of active substances is used for difficult-to-treat hypertension and in certain forms of heart failure (heart insufficiency). There are additional applications in the context of other underlying conditions, such as fluid retention in liver cirrhosis or in primary hyperaldosteronism.

Mineralocorticoid Receptor Antagonists (MRA)/Aldosterone Antagonists Effects:

Aldosterone is produced in the adrenal gland. It binds to receptors (mineralocorticoid receptors) in the kidney, leading to increased sodium and water reabsorption. As a result, blood pressure rises. When the effect of aldosterone is reduced by the occupation of the receptor by the medication, more sodium and water are excreted, and blood pressure decreases. However, this leads to increased retention of potassium in the body.

Mineralocorticoid Receptor Antagonist (MRA/Aldosterone Antagonist): Aldosterone is produced in the adrenal gland

Mineralocorticoid Receptor Antagonists (MRA)/Aldosterone Antagonists Side Effects:

An important side effect is the increased potassium level in the blood. Compared to other diuretics (see diuretics), MRAs are therefore considered potassium-sparing medications. The increased potassium in the blood can lead to muscle weakness and heart rhythm disturbances. Under the preparation spironolactone, there may be an enlargement of breast tissue in men. Rarely, liver function disorders may also occur.

Please refer to the manufacturer's information for the complete list of side effects.

Mineralocorticoid Receptor Antagonists (MRA)/Aldosterone Antagonists Active Ingredients:

Spironolactone, Eplerenone

Mineralocorticoid Receptor Antagonists (MRA)/Aldosterone Antagonists: Examples of Active Ingredients and Approved Medicinal Products

Sources:

By Dr. med. Christine Berchtold-Benchieb. This article is medically reviewed. Last updated by Sabine Croci (03/2024).
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