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Interaction of Cannabis (CBD/THC) and Medications

How do medications and cannabis interact?

Cannabis consumption is also set to be legalized in Germany. This is on the agenda of the new federal government. It is known that the consumption of marijuana and hashish is widespread in the population even without legalization. Therefore, we would like to anticipate and draw attention to possible interactions.

Interaction of Cannabis (CBD/THC) and Medications: CBD and THC are the two most well-known active ingredients of more than a hundred cannabinoids in the hemp plant Interaction of Cannabis (CBD/THC) and Medications: CBD and THC are the two most well-known active ingredients of more than a hundred cannabinoids in the hemp plant
As reported by the Pharmaceutical Journal in January 2022, interactions between cannabis and many medications are possible. The effect of the medications can be both diminished and enhanced, which can lead to potentially dangerous overdoses. This can also be inferred from the existing studies on medical cannabis as well as CBD products, which are already available. In comparison with these cannabis-based medications and THC-free CBD products, the risk of interactions during cannabis consumption increases, as the legalized "drug" is not an isolated single active ingredient, but a mixture of various substances.

It is already known, for example, that there is an interaction with the "anticoagulant" Marcumar and its generics that is, with drugs that have the same active ingredient composition but a different name. The consumption of cannabis during Marcumar therapy can result in an increased risk of bleeding. This can be dangerous, as Marcumar patients know that bleeding during Marcumar intake is difficult to stop. This applies not only to external bleeding but also, for example, to bleeding in the gastrointestinal tract. A corresponding interaction with cannabis is also possible for another group of anticoagulant medications, the direct oral anticoagulants (DOAC) such as Pradaxa (Dabigatran), Xarelto (Rivaroxaban), and Eliquis (Apixaban).

Conversely, when the anticoagulation is induced by Plavix (Clopidogrel), there can be a reduced antithrombotic (blood-thinning) effect. The risk of blood clots forming increases in this case due to cannabis consumption.

Similar interactions are described for a variety of other medications and are partly only suspected. We have taken the example of anticoagulants because this is considered proven, and anticoagulants are often prescribed for cardiovascular diseases for example, after having experienced heart attacks and strokes.

To ensure that the high does not turn into a headache, please do not hesitate to ask your pharmacist about any possible interactions with your medications if you wish to consume cannabis.

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This article is from BloodPressureDB the leading app since 2011 that supports hundreds of thousands in blood pressure monitoring every day. Our content is based on carefully researched, evidence-based data and is continuously updated (as of 03/2024).

Author Sabine Croci is a certified medical assistant with many years of experience in internal medicine and cardiology practices as well as in outpatient care, and has been leading the editorial team of BloodPressureDB since 2015. Thanks to her extensive additional qualifications as a paramedic, first responder, and in various therapy and emergency areas, she provides well-founded, practical, and reliably verified information.

We hope you found the article on the topic helpful. For good blood pressure management, it is important to take the medications correctly. Our app BloodPressureDB is happy to remind you of the intake times. It also manages the supply and informs you in good time when it is running low. This feature is also fully available in the free version. Get the free app now.


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